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More information about ABCB5 (ATP-Binding Cassette Sub-Family B Member 5) also known as P-glycoprotein ABCB5:

Scientific Papers

Sadeghi et al. Potency assay to predict the anti-inflammatory capacity of a cell therapy product for macrophage-driven diseases: Overcoming the challenges of assay development and validation. Cytotherapy 2024;26:512-523
Rendra et al. Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model. Front Immunol 2023;14:1228928
Schröder et al. Drug regulatory-compliant validation of a qPCR assay for bioanalysis studies of a cell therapy product with a special focus on matrix interferences in a wide range of organ tissues. Cells 2023;12:1788
Meshko et al. ABCB5+ limbal epithelial stem cells inhibit developmental but promote inflammatory (lymph) angiogenesis while preventing corneal inflammation. Cells 2023;12:1731
Niebergall-Roth et al. Kinetics of Wound Development and Healing Suggests a Skin-Stabilizing Effect of Allogeneic ABCB5+ Mesenchymal Stromal Cell Treatment in Recessive Dystrophic Epidermolysis Bullosa. Cells 2023;12:1468
Dieter et al. ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa. Cytotherapy 2023;25:782-788
Yan et al. ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo. Stem Cell Res Ther 2023;14:24
Niebergall-Roth et al. Skin-derived ABCB5+ mesenchymal stem cells for high-medical-need inflammatory diseases: from discovery to entering clinical routine. Int J Mol Sci 2023;24:66
Domdey et al. Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium. Stem Cell Res 2022;64:102936
Kerstan et al. Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers. Stem Cell Res Ther 2022;13:455
Nardozi et al. Potential therapeutic effects of long-term stem cell administration: impact on the gene profile and kidney function of PKD/Mhm (Cy/+) rats. J Clin Med 2022;11:2061
Singh et al. Angiogenin Released from ABCB5+ Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis. J Invest Dermatol 2022;142:1725-1736
Kerstan et al. Allogeneic ABCB5+ mesenchymal stem cells for treatment-refractory chronic venous ulcers: a phase I/IIa clinical trial. JID Innovations 2022;2:100067
Kiritsi et al. Clinical trial of ABCB5-positive mesenchymal stem cells for recessive dystrophic epidermolysis bullosa. JCI Insight 2021;6:e151922
Watanabe et al. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience 2021;24:102688
Norrick et al. Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency. Stem Cell Res Ther 2021;12:194
Harrell et al. The role of Interleukin 1 receptor antagonist in mesenchymal stem cell-based tissue repair and regeneration. BioFactors. 2020;46:263-275
Jiang et al. Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing. Front Cell Dev Biol 2020;8:697
Riedl et al. ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for Recessive Dystrophic Epidermolysis Bullosa treatment. Stem Cells 2021;39:897-903
Kerstan et al. Ex-vivo expanded highly pure ABCB5+ mesenchymal stromal cells as GMP-conform autologous ATMP for clinical use: Process validation and first-in-human data. Cytotherapy 2021;23:165-175
Ballikaya et al. Process data of allogeneic ex vivo-expanded ABCB5+ mesenchymal stromal cells for human use: Off-the-shelf GMP-manufactured donor-independent ATMP. Stem Cell Res Ther 2020;11:482
Klicks et al. A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells. BMC Cancer 2019;19:402
Hartwig et al. Human skin derived ABCB5+ stem cell injection improves liver disease parameters in Mdr2KO mice. Arch Toxicol 2019;93:2645-2660
Vander Beken et al., Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist. Stem Cells 2019;37:1057–1074
Tappenbeck et al. In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials. Cytotherapy 2019;21:546-560
Notara et al. UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation. Sci Rep 2018;8:12564
Tietze et al. Assessment of the hepatocytic differentiation ability of human skin-derived ABCB5+ stem cells. Exp Cell Res 2018;369:335-347
Borchers et al. Detection of ABCB5 tumour antigen-specific CD8+ T cells in melanoma patients and implications for immunotherapy. Clin Exp Immunol 2017;191:74-83
Webber et al. Rapid generation of Col7a1−/− mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells. Lab Invest 2017;97:1218-1224
Schatton et al. ABCB5 identifies immunoregulatory dermal cells. Cell Rep. 2015 Sep 8; 12(10): 1564–1574
Ksander et al. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature 2014;511:353-357

ABCB5-positive Mesenchymal Stem Cells (ABCB5+)

Stem Cells

Wikipedia (free encyclopedia)

ABCB5 Wikipedia article